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No. According to the current scientific evidence the fructose consumption per se does not have any negative impact on health and does not lead to unhealthy weight gain.

As explained by the World Health Organisation (WHO1), the fundamental cause of obesity is an energy imbalance between calories consumed and calories expended. Eating more calories than required by our body can lead to unhealthy weight gain.

Fructose is naturally present in fruit and fruit juices, honey or nectars. In combination with glucose, fructose also forms other sugars, such as table sugar (produced from cane or sugar beet) or glucose-fructose syrups (produced from maize or wheat starch).

Fructose found in juices and honey is digested and metabolised by the human body exactly the same way as fructose found in table sugar or glucose-fructose syrups; there is no difference whether it comes from natural sources or from sugar added during preparation.

1World Health Organisation: Obesity and overweight Fact sheet –
http://www.who.int/mediacentre/factsheets/fs311/en/